Etanercept With IVIg for Acute Kawasaki Disease: A Randomized Controlled Trial.

ABSTRACT:

Objectives

Patients with Kawasaki disease can develop life-altering coronary arterial abnormalities, particularly in those resistant to intravenous immunoglobulin (IVIg) therapy. We tested the tumor necrosis factor α receptor antagonist etanercept for reducing both IVIg resistance and coronary artery (CA) disease progression.

Methods

In a double-blind multicenter trial, patients with Kawasaki disease received either etanercept (0.8 mg/kg; n = 100) or placebo (n = 101) subcutaneously starting immediately after IVIg infusion. IVIg resistance was the primary outcome with prespecified subgroup analyses according to age, sex, and race. Secondary outcomes included echocardiographic CA measures within subgroups defined by coronary dilation (z score >2.5) at bas

SUBMITTER: Portman MA 

PROVIDER: S-EPMC6564061 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature