Temporal increases in 25-hydroxyvitamin D in midlife women: Longitudinal results from the Study of Women's Health Across the Nation.

ABSTRACT:

Objective

25-hydroxyvitamin D (25(OH)D) is critical for bone mineralization and may prevent fractures. Understanding vitamin D deficiency trends in midlife women is particularly important given their concurrent menopausal changes that increase risk for fracture. We aimed to evaluate changes in mean 25(OH)D over time and their determinants in a racially, ethnically and socioeconomically diverse cohort of midlife women.

Design

A multi-centre prospective cohort study.

Patients

1585 women ages 42-52 years at baseline.

Measurements

We measured serum 25(OH)D at 2 time points (1998-2000 and 2009-2011). Between-visit change was assessed in the whole cohort and in socioeconomic and demographic subgroups. Among those with vitamin D deficiency (25(OH)D <30 nmol/L) at base

SUBMITTER: Mitchell DM 

PROVIDER: S-EPMC6565441 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature