Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups With Differing Risks of Liver Metastases.

ABSTRACT:

Objective

The aim of this study was to investigate the key molecular alterations in small primary pancreatic neuroendocrine tumors (PanNETs) associated with the development of liver metastases.

Background

Well-differentiated PanNETs with small size are typically indolent; however, a limited subset metastasize to the liver.

Methods

A total of 87 small primary PanNETs (<3 cm), including 32 metastatic cases and 55 nonmetastatic cases after a 5-year follow-up, were immunolabeled for DAXX/ATRX and analyzed for alternative lengthening of telomeres (ALT) by Fluorescence In Situ Hybridization. A subset of these cases, 24 that metastasized and 24 that did not metastasize, were assessed by targeted next-generation sequencing and whole-genome copy number variation.

Results

SUBMITTER: Pea A 

PROVIDER: S-EPMC6565500 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature