Neurite orientation dispersion and density imaging of mouse brain microstructure.

ABSTRACT: Advanced biophysical models like neurite orientation dispersion and density imaging (NODDI) have been developed to estimate the microstructural complexity of voxels enriched in dendrites and axons for both in vivo and ex vivo studies. NODDI metrics derived from high spatial and angular resolution diffusion MRI using the fixed mouse brain as a reference template have not yet been reported due in part to the extremely long scan time required. In this study, we modified the three-dimensional diffusion-weighted spin-echo pulse sequence for multi-shell and undersampling acquisition to reduce the scan time. This allowed us to acquire several exhaustive datasets that would otherwise not be attainable. NODDI metrics were derived from a complex 8-shell diffusion (1000-8000 s/mm²) dataset

SUBMITTER: Wang N 

PROVIDER: S-EPMC6565502 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature