Association of OPG gene polymorphisms with the risk of knee osteoarthritis among Chinese people.

ABSTRACT:

Background

Osteoarthritis (OA) is usually recognized to have a genetic factor, and in our study, we performed a case-control study to analyze the association between 14 single nucleotide polymorphisms (SNPs) in OPG and the risk of knee OA in a Chinese Han population.

Methods

Fourteen OPG SNPs were assayed using MassARRAY in 393 patients clinically and radiographically diagnosed with knee OA and in 500 controls. Allelic and genotypic frequencies were compared between the groups. Logistic regression adjusting for age and gender was used to estimate risk associations between specific genotypes and knee OA by computing odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results

We found that the minor alleles of six SNPs in OPG were associated with an increased or d

SUBMITTER: Qi Y 

PROVIDER: S-EPMC6565555 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature