Transcriptome analysis identifies metallothionein as biomarkers to predict recurrence in hepatocellular cacinoma.

ABSTRACT:

Background

Liver cancer is the fifth most common cancer, and hepatocellular carcinoma (HCC) is the major liver tumor type seen in adults. HCC is usually caused by chronic liver disease such as hepatitis B virus or hepatitis C virus infection. One of the promising treatments for HCC is liver transplantation, in which a diseased liver is replaced with a healthy liver from another person. However, recurrence of HCC after surgery is a significant problem. Therefore, it is important to discover reliable cellular biomarkers that can predict recurrence in HCC.

Methods

We analyzed previously published HCC RNA-Seq data that includes 21 paired tumor and normal samples, in which nine tumors were recurrent after orthotopic liver transplantation and 12 were nonrecurrent tumors with their

SUBMITTER: Wang S 

PROVIDER: S-EPMC6565558 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature