Maternal genetic markers for risk of celiac disease and their potential association with neural tube defects in offspring.

ABSTRACT:

Background

We examined the association between the maternal genotype for celiac disease-associated variants and risk of neural tube defects (NTDs).

Methods

We conducted a case-control study, using data from the National Birth Defects Prevention Study. We evaluated 667 cases (women with an offspring with NTD) and 743 controls (women with an offspring without a birth defect). We classified women as having low, intermediate, or high risk of celiac disease based on human leukocyte antigen (HLA) variants. We used logistic regression to assess the relationship between HLA celiac risk group (low, intermediate, high) and risk of NTDs. Fifteen non-HLA variants (identified from genome-wide association studies of celiac disease) were individually evaluated and modeled additively.

Re

SUBMITTER: Hoang TT 

PROVIDER: S-EPMC6565562 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature