Comparison of gene mutation spectrum of thalassemia in different regions of China and Southeast Asia.

ABSTRACT:

Background

Thalassemia is a common genetic disorder. High prevalence of thalassemia is found in South China, Southeast Asia, India, the Middle East, and the Mediterranean regions. Thalassemia was thought to exist only in southern China, but an increasing number of cases from northern China have been recently reported.

Methods

During 2012 to 2017, suspected thalassemia people were detected for common α- and β-thalassemia mutations by gap-Polymerase Chain Reaction (PCR) and reverse dot blot (RDB) analysis in Peking Union Medical College Hospital. One thousand and fifty-nine people with thalassemia mutations were analyzed retrospectively. We picked mutated individuals who originally came from northern areas, and conducted telephone follow-up survey in order to collect their anc

SUBMITTER: Yang Z 

PROVIDER: S-EPMC6565565 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature