Dataset Information

Prioritization and comprehensive analysis of genes related to major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is a serious mental health problem in modern society, which is difficult to identify and diagnose in the early stages. Despite strong evidence supporting the heritability of MDD, progresses in large-scale and individual genetic studies remain preliminary.

Methods

In this study, a multi-data source-based prioritization (MDSP) method was proposed, and an appropriate threshold was determined for the optimization of depression-related genes (DEPgenes). Analyses on Gene Ontology biological processes, KEGG pathway and the specific pathway crosstalk network were further proposed.