Association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population.

ABSTRACT:

Background

Colorectal cancer is the third most common cancer worldwide. Recently, an increasing number of evidences suggest that genetic susceptibility plays an important role in the occurrence of colorectal cancer. This study aimed to better understand the influence of MIR17HG polymorphisms on colorectal cancer susceptibility in the Chinese Han population.

Methods

We recruited 514 patients with colorectal cancer and 510 healthy controls to investigate the association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population. Genotyping was performed with the Agena MassARRAY platform. We used the χ² test to compare the distributions of single nucleotide polymorphisms (SNPs) allele and genotypes frequencies between cases and contr

SUBMITTER: Chen P 

PROVIDER: S-EPMC6565593 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature