In search of a rodent model of placebo analgesia in chronic orofacial neuropathic pain.

ABSTRACT: All treatments are given in a context, suggesting that conditioning cues may significantly influence therapeutic outcomes. We tested the hypothesis that context affects placebo analgesia in rodents. To produce neuropathic pain in rats, we performed chronic constriction injury of the infraorbital nerve. We then treated the rats daily, over a seven day period, with injections of either fentanyl or saline, with or without associated conditioning cues; a fourth group received no treatment. On the eighth day, we replaced fentanyl with saline to test for conditioned placebo analgesia. We tested the effects of treatment by measuring sensitivity to mechanical stimuli and grimace scale scores. We found no significant differences in either of these outcomes among the four experimental groups. These

SUBMITTER: Akintola T 

PROVIDER: S-EPMC6565753 | biostudies-literature | 2019 Aug-Dec

REPOSITORIES: biostudies-literature