Alterations in brain neurocircuitry following treatment with the chemotherapeutic agent paclitaxel in rats.

ABSTRACT: Human and animal studies suggest that both traumatic nerve injury and toxic challenge with chemotherapeutic agents involves the reorganization of neural circuits in the brain. However, there have been no prospective studies, human or animal, using magnetic resonance imaging (MRI) to identify changes in brain neural circuitry that accompany the development of chemotherapy-induced neuropathic pain (i.e. within days following cessation of chemotherapy treatment and without the confound cancer). To this end, different MRI protocols were used to ascertain whether a reorganization of brain neural circuits is observed in otherwise normal rats exposed to the taxane chemotherapeutic agent paclitaxel. We conducted an imaging study to evaluate the impact of a well-established paclitaxel dosing regime

SUBMITTER: Ferris CF 

PROVIDER: S-EPMC6565758 | biostudies-literature | 2019 Aug-Dec

REPOSITORIES: biostudies-literature