High-density lipoprotein (HDL) particle size and concentration changes in septic shock patients.

ABSTRACT:

Background

Sepsis is associated with systemic inflammation that may impact lipoprotein function. In particular, high-density lipoproteins (HDLs) that display pleiotropic protective roles may be dysfunctional in septic conditions. The aim of this study was to evaluate the HDL profile and the inflammatory context in septic shock patients admitted to our intensive care unit (ICU).

Methods

In this study, 20 septic shock patients and 20 controls (ICU patients without septic shock) were included. Plasma samples were collected on days 1, 2 and 7. Total cholesterol and lipoprotein concentrations were determined. HDL profiles were obtained using the Lipoprint^® System (non-denaturing electrophoresis). Quantification of pro-inflammatory cytokines (interleukin 1b, 6 and 8), c

SUBMITTER: Tanaka S 

PROVIDER: S-EPMC6565796 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature