Large-scale brain modes reorganize between infant sleep states and carry prognostic information for preterms.

ABSTRACT: Sleep architecture carries vital information about brain health across the lifespan. In particular, the ability to express distinct vigilance states is a key physiological marker of neurological wellbeing in the newborn infant although systems-level mechanisms remain elusive. Here, we demonstrate that the transition from quiet to active sleep in newborn infants is marked by a substantial reorganization of large-scale cortical activity and functional brain networks. This reorganization is attenuated in preterm infants and predicts visual performance at two years. We find a striking match between these empirical effects and a computational model of large-scale brain states which uncovers fundamental biophysical mechanisms not evident from inspection of the data. Active sleep is defined by re

SUBMITTER: Tokariev A 

PROVIDER: S-EPMC6565810 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature