Effects of interleukin-6 receptor blockade on allergen-induced airway responses in mild asthmatics.

ABSTRACT:

Background

Interleukin (IL)-6 signalling has been implicated in allergic asthma by animal, genetic association and clinical studies. In this study, we tested the hypothesis that tocilizumab (TCZ), a human monoclonal antibody that blocks IL-6 signalling, can prevent the development of allergen-induced bronchoconstriction in humans.

Methods

We performed a randomised, double-blind, placebo-controlled study, with eligible participants completing two allergen inhalation challenge tests, conducted before and after treatment with a single dose of TCZ or placebo. The primary efficacy endpoint was the magnitude of the late asthmatic response recorded between 3 and 7 after allergen challenge. The secondary efficacy endpoint was the early asthmatic response, measured 20 min to 2 h afte

SUBMITTER: Revez JA 

PROVIDER: S-EPMC6566140 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature