Nano-Carriers Based on pH-Sensitive Star-Shaped Copolymers for Drug-Controlled Release.

ABSTRACT: Polymeric nano-carriers are considered as promising tools in biomedical applications due to multiple attractive characteristics including their low toxicity, high loading capacity, controlled drug release capabilities, and highly tunable chemical properties. Here, a series of pH-sensitive star-shaped copolymers, Ad-P[(EMA-co-MAA)-b-PPEGMA]4, was prepared via electron transfer atom radical polymerization (ARGETE ATRP) and selective hydrolysis. These star-shaped copolymers can be self-assembled into micelles (Dh = 150-160 nm) and their critical micelle concentrations (CMC) were estimated to be 3.9-5.0 mg/L. The pH-sensitiveness of the micelles was evidenced by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The maximal paclitaxel (PTX) loading efficiency (DLC) and

SUBMITTER: Jiang W 

PROVIDER: S-EPMC6566147 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature