Cyclodextrin⁻Amphiphilic Copolymer Supramolecular Assemblies for the Ocular Delivery of Natamycin.

ABSTRACT: Natamycin is the only drug approved for fungal keratitis treatment, but its low water solubility and low ocular penetration limit its efficacy. The purpose of this study was to overcome these limitations by encapsulating the drug in single or mixed micelles and poly(pseudo)rotaxanes. Soluplus and Pluronic P103 dispersions were prepared in 0.9% NaCl and pH 6.4 buffer, with or without α-cyclodextrin (αCD; 10% w/v), and characterized through particle size, zeta potential, solubilization efficiency, rheological properties, ocular tolerance, in vitro drug diffusion, and ex vivo permeation studies. Soluplus micelles (90-103 nm) and mixed micelles (150-110 nm) were larger than Pluronic P103 ones (16-20 nm), but all showed zeta potentials close to zero. Soluplus, Pluronic P103, and their mixed mic

SUBMITTER: Lorenzo-Veiga B 

PROVIDER: S-EPMC6566826 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature