Comparative study of the antidiabetic potential of Paederia foetida twig extracts and compounds from two different locations in Malaysia.

ABSTRACT: Context: Paederia foetida L. (Rubiaceae) is an edible plant distributed in Asian countries including Malaysia. Fresh leaves have been traditionally used as a remedy for indigestion and diarrhea. Several phytochemical studies of the leaves have been documented, but there are few reports on twigs. Objective: This study investigates the enzyme inhibition of P. foetida twig extracts and compound isolated from them. In addition, in silico molecular docking of scopoletin was investigated. Materials and methods: Plants were obtained from two locations in Malaysia, Johor (PFJ) and Pahang (PFP). Hexane, chloroform and methanol extracts along with isolated compound (scopoletin) were evaluated for their enzyme inhibition activities (10,000-0.000016 µg/mL). Th

SUBMITTER: Tan DC 

PROVIDER: S-EPMC6566874 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature