Estimated nationwide impact of implementing a preemptive pharmacogenetic panel approach to guide drug prescribing in primary care in The Netherlands.

ABSTRACT:

Background

Pharmacogenetics (PGx) is currently implemented in hospitals to optimize therapy with high-risk drugs. However, many drugs with dosing recommendations from the Dutch Pharmacogenetics Working Group and the Clinical Pharmacogenetics Implementation Consortium are used in primary care. Actionable phenotypes for the genes covered in these guidelines are common with estimates ranging from 85 to 95% of the population carrying at least one actionable phenotype. The goal of this study was to estimate the clinical impact of implementation of an upfront panel-based pharmacogenetic screening for eight genes related to drugs used in primary care for 2016.

Methods

For this study, dispensing data concerning first prescription for the period January 1-December 31, 2016, were comb

SUBMITTER: Bank PCD 

PROVIDER: S-EPMC6567386 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature