Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a ¹H NMR-based metabolomics study.

ABSTRACT:

Background

Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study, a proton nuclear magnetic resonance (¹H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered metabolic profiles in blood serum and urine samples obtained from HAE patients. The aim of the study was to identify the metabolic signatures associated with HAE.

Results

A total of 21 distinct metabolic differences between HAE patients and healthy individuals were identified, and they are assoc

SUBMITTER: Lin C 

PROVIDER: S-EPMC6567409 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature