SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway.

ABSTRACT:

Background

Optimal therapeutic strategies for hepatocellular carcinoma (HCC) patients are still challenging due to the high recurrence rate after surgical resection and chemotherapy resistance. Growing evidence shows that genetic and epigenetic alterations are involved in HCC progression and resistance to therapy, however the molecular mechanisms underlying resistance to therapy have not been fully understood.

Methods

Expression of SIRT7 in 17 paired paraffin-embedded HCC tissues and adjacent nontumoral liver tissues was examined by immunohistochemistry and Western blot. The mRNA expression of SIRT7 in 20 paired frozen HCC tissues and adjacent nontumoral liver tissues was analyzed by quantitative RT-PCR. The biologic consequences of overexpression and knockdown of SIRT7 in H

SUBMITTER: Zhao J 

PROVIDER: S-EPMC6567523 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature