Regional Behavior of Airspaces During Positive Pressure Reduction Assessed by Synchrotron Radiation Computed Tomography.

ABSTRACT:

Introduction

The mechanisms of lung inflation and deflation are only partially known. Ventilatory strategies to support lung function rely upon the idea that lung alveoli are isotropic balloons that progressively inflate or deflate and that lung pressure/volume curves derive only by the interplay of critical opening pressures, critical closing pressures, lung history, and position of alveoli inside the lung. This notion has been recently challenged by subpleural microscopy, magnetic resonance, and computed tomography (CT). Phase-contrast synchrotron radiation CT (PC-SRCT) can yield in vivo images at resolutions higher than conventional CT.

Objectives

We aimed to assess the numerosity (ASden) and the extension of the surface of airspaces (ASext) in healthy conditions a

SUBMITTER: Scaramuzzo G 

PROVIDER: S-EPMC6567926 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature