Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells.

ABSTRACT: Pharmacological inhibition of microsomal prostaglandin E synthase (mPGES)-1 for selective reduction in prostaglandin E₂ (PGE₂) biosynthesis is protective in experimental models of cancer and inflammation. Targeting mPGES-1 is envisioned as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs). Herein, we compared the effects of mPGES-1 inhibitor Compound III (CIII) with the cyclooxygenase (COX)-2 inhibitor NS-398 on protein and lipid profiles in interleukin (IL)-1β-induced A549 lung cancer cells using mass spectrometry. Inhibition of mPGES-1 decreased PGE₂ production and increased PGF_2α and thromboxane B₂ (TXB₂) formation, while inhibition of COX-2 decreased the production of all three prostanoids

SUBMITTER: Bergqvist F 

PROVIDER: S-EPMC6567928 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature