Systems biology approaches to identify disease mechanisms and facilitate targeted therapy in the management of glomerular disease.

ABSTRACT:

Purpose of review

Current clinical pathological classifications of glomerular diseases are inadequate at predicting patient disease progression or response to therapy. With the advent of precision medicine and its successes in oncology, it is important to understand if similar approaches in glomerular diseases can improve patient management. The purpose of this review is to summarize approaches to obtain comprehensive molecular profiles from human biopsies and utilize them to define the pathophysiology of glomerular failure.

Recent findings

Multicenter research networks have provided the framework to capture both prospective clinical disease course and patterns of end organ damage in biopsy cohorts. With these sample and data sets in hand, efforts are progressing towards mol

SUBMITTER: Hamidi H 

PROVIDER: S-EPMC6568000 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature