Baicalein Exerts Neuroprotective Effects in FeCl₃-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis.

ABSTRACT: Posttraumatic epilepsy (PTE) is a prevalent type of acquired epilepsy secondary to traumatic brain injury, and is characterized by repeated seizures. Traditional antiepileptic drugs have minimal response in preventing posttraumatic epileptic seizures. It is essential for the development of new therapeutic strategy. Our previous work disclosed a potent neuroprotective role of baicalein, a flavonoid extracted from Scutellaria baicalensis Georgi, against inherited epilepsy in rats. Whether baicalein has protective potential in posttraumatic epileptic seizures and the possible molecular mechanism remain elusive. Additionally, the brain is vulnerable to lipid peroxidation-induced damage due to high consumption of oxygen and abundant polyunsaturated fatty acids in neuronal membranes. Our

SUBMITTER: Li Q 

PROVIDER: S-EPMC6568039 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature