Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life.

ABSTRACT: Antibodies and Fc-fusion antibody-like proteins have become successful biologics developed for cancer treatment, passive immunity against infection, addiction, and autoimmune diseases. In general these biopharmaceuticals can be used for blocking protein:protein interactions, crosslinking host receptors to induce signaling, recruiting effector cells to targets, and fixing complement. With the vast capability of antibodies to affect infectious and genetic diseases much effort has been placed on improving and tailoring antibodies for specific functions. While antibody:antigen engagement is critical for an efficacious antibody biologic, equally as important are the hinge and constant domains of the heavy chain. It is the hinge and constant domains of the antibody that engage host receptors or

SUBMITTER: Saunders KO 

PROVIDER: S-EPMC6568213 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature