CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans.

ABSTRACT: Macrophages play central roles in inflammatory reactions and initiation of immune responses during infections. More than 80% of total tissue macrophages are described to be located in the liver as liver-resident macrophages, also named Kupffer cells (KCs). While studies in mice have established a central role of liver-resident KCs in regulating liver inflammation, their phenotype and function are not well-characterized in humans. Comparing paired human liver and peripheral blood samples, we observed significant differences in the distribution of macrophage (Mφ) subsets, with lower frequencies of CD14^hiCD16^lo and higher frequencies of CD14^int-hiCD16^int Mφ in human livers. Intrahepatic Mφ consisted of diverse subsets with differential expression of

SUBMITTER: Martrus G 

PROVIDER: S-EPMC6568245 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature