PGM5: a novel diagnostic and prognostic biomarker for liver cancer.

ABSTRACT:

Background

Liver cancer is a common malignancy and a significant public health problem worldwide, but diagnosis and prognostic evaluation remain challenging for clinicians. Metabolic reprogramming is a hallmark of cancer, and we therefore examined the diagnostic and prognostic value of a metabolic enzyme, phosphoglucomutase-like protein 5 (PGM5), in liver cancer.

Methods

All data were from The Cancer Genome Atlas database. R and related statistical packages were used for data analysis. Hepatic PGM5 expression was determined in different groups, and the chi-squared test and Fisher's exact test were used to determine the significance of differences. The pROC package was used to determine receiver operating characteristic (ROC) curves, the survival package was used to fo

SUBMITTER: Jiao Y 

PROVIDER: S-EPMC6568247 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature