The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Acetyl-CoA carboxylase (ACC) plays an important role in the metabolism of various cancer cells, but its role in head and neck squamous cell carcinoma (HNSCC) is uncertain. Therefore, in the present study, we explored the role of ACC2 in HNSCC.

Methods

Western blot and immunohistochemistry assays were used to determine ACC2 protein expression levels in laryngocarcinoma and adjacent normal tissues derived from patients with laryngocarcinoma. ACC2 expression was knocked down in the hypopharyngeal cancer cell line FaDu to determine its effect on apoptosis. Lipid oil red staining was used to test the change of intracellular lipid.

Results

The results showed that the ACC2 protein was highly expressed in laryngocarcinoma and that the ACC2 expression level was posi

SUBMITTER: Li K 

PROVIDER: S-EPMC6568254 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature