S-Block cooperative catalysis: alkali metal magnesiate-catalysed cyclisation of alkynols.

ABSTRACT: Mixed s-block metal organometallic reagents have been successfully utilised in the catalytic intramolecular hydroalkoxylation of alkynols. This success has been attributed to the unique manner in which these reagents can overcome the challenges of the reaction: namely OH activation and coordination to and then addition across a C[triple bond, length as m-dash]C bond. In order to optimise the reaction conditions and to garner vital catalytic system requirements, a series of alkali metal magnesiates were enlisted for the catalytic intramolecular hydroalkoxylation of 4-pentynol. In a prelude to the main investigation, the homometallic magnesium dialkyl reagent MgR₂ (where R = CH₂SiMe₃) was utilised. This reagent was unsuccessful in cyclising the alcohol into 2

SUBMITTER: Fairley M 

PROVIDER: S-EPMC6568277 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature