Vitamin D supplementation for prevention of cancer: The D2d cancer outcomes (D2dCA) study.

ABSTRACT: Evidence on biological plausibility from mechanistic studies and data from observational studies suggest that vitamin D may be linked to risk of several types of cancer. However, evidence from clinical trials evaluating the effect of vitamin D supplementation on cancer risk is limited. The Vitamin D and Type 2 Diabetes (D2d) study is a multi-center, randomized, placebo-controlled clinical trial conducted to examine the causal relationship between oral vitamin D supplementation and development of diabetes among overweight adults with prediabetes. The D2d study provides a unique opportunity to assess the effect of vitamin D supplementation at a higher dose (4000 IU/day) than has been used in other clinical trials with cancer outcomes, in a population at higher than average risk for cancer. T

SUBMITTER: Chatterjee R 

PROVIDER: S-EPMC6570503 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature