CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells.

ABSTRACT: CTLA-4 is a critical negative regulator of the immune system and a major target for immunotherapy. However, precisely how it functions in vivo to maintain immune homeostasis is not clear. As a highly endocytic molecule, CTLA-4 can capture costimulatory ligands from opposing cells by a process of transendocytosis (TE). By restricting costimulatory ligand expression in this manner, CTLA-4 controls the CD28-dependent activation of T cells. Regulatory T cells (T_regs) constitutively express CTLA-4 at high levels and, in its absence, show defects in TE and suppressive function. Activated conventional T cells (T_conv) are also capable of CTLA-4-dependent TE; however, the relative use of this mechanism by T_regs and T_conv in vivo remains unclear. Here, we

SUBMITTER: Ovcinnikovs V 

PROVIDER: S-EPMC6570622 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature