Evaluating diagnostic strategies for early detection of cancer: the CanTest framework.

ABSTRACT:

Background

Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and quality of care, while minimising over-investigation and over-diagnosis.

Methods

We performed a systematic scoping review of frameworks for the evaluation of tests and diagnostic approaches.

Results

We identified 16 frameworks: none addressed the entire continuum from test developmen

SUBMITTER: Walter FM 

PROVIDER: S-EPMC6570853 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature