Translational formulation of nanoparticle therapeutics from laboratory discovery to clinical scale.

ABSTRACT:

Background

"Nanomedicine" is the application of purposely designed nano-scale materials for improved therapeutic and diagnostic outcomes, which cannot be otherwise achieved using conventional delivery approaches. While "translation" in drug development commonly encompasses the steps from discovery to human clinical trials, a different set of translational steps is required in nanomedicine. Although significant development effort has been focused on nanomedicine, the translation from laboratory formulations up to large scale production has been one of the major challenges to the success of such nano-therapeutics. In particular, scale-up significantly alters momentum and mass transfer rates, which leads to different regimes for the formation of nanomedicines. Therefore, unlike the co

SUBMITTER: Feng J 

PROVIDER: S-EPMC6570894 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature