Effect of heat-killed Streptococcus thermophilus on type 2 diabetes rats.

ABSTRACT:

Background and aims

The link between gut microbiota and type 2 diabetes (T2D) has been addressed by numerous studies. Streptococcus thermophilus from fermented milk products, has been used as a probiotic in previous research. However, whether heat-killed S. thermophilus can improve the glycemic parameters of diabetic rats remains unanswered. In this study, we evaluated the effect of heat-killed S. thermophilus on T2D model rats and the potential mechanisms of the effect.

Methods

Zucker diabetic fatty (ZDF) rats were used to generate a diabetic rat model induced by feeding a high-fat diet. Heat-killed S. thermophilus were orally administered to normal and diabetic rats for 12 weeks. Intestinal microbiota analysis, histology analysis, oral glucose t

SUBMITTER: Gao X 

PROVIDER: S-EPMC6571132 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature