Myo-inositol mediates the effects of traffic-related air pollution on generalized anxiety symptoms at age 12 years.

ABSTRACT:

Background

Exposure to traffic-related air pollution (TRAP) has been linked to childhood anxiety symptoms. Neuroimaging in patients with anxiety disorders indicate altered neurochemistry.

Objectives

Evaluate the impact of TRAP on brain metabolism and its relation to childhood anxiety symptoms in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS).

Methods

Adolescents (n = 145) underwent magnetic resonance spectroscopy. Brain metabolites, including myo-inositol, N-acetylaspartate, creatine, choline, glutamate, glutamate plus glutamine, and glutathione were measured in the anterior cingulate cortex. Anxiety symptoms were assessed using the Spence Children's Anxiety Scale. TRAP exposure in early-life, averaged over childhood, and during the 12 months prior

SUBMITTER: Brunst KJ 

PROVIDER: S-EPMC6571158 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature