In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children.

ABSTRACT:

Background

Maternal smoking during pregnancy is a risk factor for chronic disease later in life and has been associated with variability of DNA methylation at specific cytosine-phosphate-guanine (CpG) loci. We assessed the role of DNA methylation as a potential mediator of adverse effects of in utero tobacco smoke exposures on asthma outcomes in Latino children from the US mainland and Puerto Rico.

Methods

Relationships between self-reported exposure and DNA methylation at CpG loci previously reported to be associated with maternal smoking were assessed in a subsample consisting of 572 children aged 8-21 years (310 cases with asthma, 262 healthy controls), sampled from a larger asthma case-control study. Subsequently, we assessed associations between top loci and asthma-rela

SUBMITTER: Neophytou AM 

PROVIDER: S-EPMC6571182 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature