Salivary Cystatin SN Binds to Phytic Acid In Vitro and Is a Predictor of Nonheme Iron Bioavailability with Phytic Acid Supplementation in a Proof of Concept Pilot Study.

ABSTRACT:

Background

Acute phytic acid intake has been found to decrease iron bioavailability; however, repeated phytic acid consumption leads to iron absorption adaptation. Salivary proline-rich proteins (PRPs) have been shown to inhibit iron chelation to tannins and may mediate similar iron absorption adaptation with phytic acid intake.

Objectives

The objectives of this study were to determine whether salivary proteins bind to phytic acid in vitro, and to explore a proof of concept in a pilot study that examined the impact of 4-wk, daily phytic acid supplementation on individuals' iron status, bioavailability, and salivary PRP concentrations.

Methods

High-performance liquid chromatography (HPLC) and matrix-assisted laser desorption/ionization-time of flight were used to chara

SUBMITTER: Delimont NM 

PROVIDER: S-EPMC6571437 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature