Evidence of Trained Immunity in a Fish: Conserved Features in Carp Macrophages.

ABSTRACT: Trained immunity is a form of innate immune memory best described in mice and humans. Clear evidence of the evolutionary conservation of trained immunity in teleost fish is lacking. Given the evolutionary position of teleosts as early vertebrates with a fully developed immune system, we hypothesize that teleost myeloid cells show features of trained immunity common to those observed in mammalian macrophages. These would at least include the ability of fish macrophages to mount heightened responses to a secondary stimulus in a nonspecific manner. We established an in vitro model to study trained immunity in fish by adapting a well-described culture system of head kidney-derived macrophages of common carp. A soluble NOD-specific ligand and a soluble β-glucan were used to train carp macrophag

SUBMITTER: Petit J 

PROVIDER: S-EPMC6571502 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature