Can Metabolic Pathways Be Therapeutic Targets in Rheumatoid Arthritis?

ABSTRACT: The metabolic rewiring of tumor cells and immune cells has been viewed as a promising source of novel drug targets. Many of the molecular pathways implicated in rheumatoid arthritis (RA) directly modify synovium metabolism and transform the resident cells, such as the fibroblast-like synoviocytes (FLS), and the synovial tissue macrophages (STM), toward an overproduction of enzymes, which degrade cartilage and bone, and cytokines, which promote immune cell infiltration. Recent studies have shown metabolic changes in stromal and immune cells from RA patients. Metabolic disruption in the synovium provide the opportunity to use in vivo metabolism-based imaging techniques for patient stratification and to monitor treatment response. In addition, these metabolic changes may be therapeutically ta

SUBMITTER: Sanchez-Lopez E 

PROVIDER: S-EPMC6572063 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature