Gut Microbial Composition and Function Are Altered in Patients with Early Rheumatoid Arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation of the joints and extra-articular manifestations. Recent studies have shown that microorganisms affect RA pathogenesis. However, few studies have examined the microbial distribution of early RA patients, particularly female patients. In the present study, we investigated the gut microbiome profile and microbial functions in early RA female patients, including preclinical and clinically apparent RA cases. Changes in microbiological diversity, composition, and function in each group were analyzed using quantitative insights into microbial ecology (QIIME) and phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt). The results revealed the dysbiosis due to decreased div

SUBMITTER: Jeong Y 

PROVIDER: S-EPMC6572219 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature