Fe₃O₄ Nanoparticles Functionalized with Polymer Ligand for T₁-Weighted MRI In Vitro and In Vivo.

ABSTRACT: Magnetic resonance imaging (MRI) has gained wide interest in early accurate diagnoses due to the high resolution and low toxicity of magnetic nanoparticles. In order to develop potential alternatives of toxic Gd- or Mn-based chelating agents, we report the synthesis of water soluble ultra-small Fe₃O₄ nanoparticles by a modified co-precipitation method as T₁-weighted positive contrast agents. The magnetic iron oxide nanoparticles (MIONs) were functionalized by polymer ligand dodecanthiol-polymethacrylic acid (DDT-PMAA) to enhance their colloidal stability. These MIONs have high longitudinal relaxivity (r₁ = 8.18 mM^-1·S^-1) and exhibited good results in the in vitro and in vivo MR imaging. No toxicity was observed in cyt

SUBMITTER: Xiang C 

PROVIDER: S-EPMC6572598 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature