Effects of MTHFR and ABCC2 gene polymorphisms on antiepileptic drug responsiveness in Jordanian epileptic patients.

ABSTRACT:

Background

Epilepsy is one of the most common neurological diseases with unclear etiology where its genetic background and treatment regime still need further exploration.

Objectives

This study designed to evaluate the pharmacogenomics of MTHFR and ABCC2 genes, and their association with epilepsy susceptibility among Jordanian population.

Methods

A case-control study was conducted on Jordanian cohort of 296 epileptic patients and 299 healthy individuals. Custom platform array was used to genotype the genetic polymorphisms within MTHFR (rs1801133) and ABCC2 (rs717620, rs3740066, rs2273697) genes.

Results

This study revealed a significant genetic association of MTHFR rs1801133 polymorphism with susceptibility to generalized in general

SUBMITTER: Al-Eitan LN 

PROVIDER: S-EPMC6572658 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature