Dataset Information
Pharmacotherapies that specifically target ammonia for the prevention and treatment of hepatic encephalopathy in adults with cirrhosis.
Ontology highlight
ABSTRACT:
SUBMITTER: Zacharias HD
PROVIDER: S-EPMC6572872 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Pharmacotherapies that specifically target ammonia for the prevention and treatment of hepatic encephalopathy in adults with cirrhosis.
The Cochrane database of systematic reviews 20190617
<h4>Background</h4>Hepatic encephalopathy is a common complication of cirrhosis, with high related morbidity and mortality. Its presence is associated with a wide spectrum of change ranging from clinically obvious neuropsychiatric features, known as 'overt' hepatic encephalopathy, to abnormalities manifest only on psychometric or electrophysiological testing, 'minimal' hepatic encephalopathy. The exact pathogenesis of the syndrome is unknown but ammonia plays a key role. Drugs that specifically ...[more]