CDK 4/6 Inhibitors in Breast Cancer: Current Controversies and Future Directions.

ABSTRACT:

Purpose of review

To describe the clinical role of CDK 4/6 inhibitors in hormone receptor-positive (HR+) metastatic breast cancer (HR+ MBC) as well as current controversies and evolving areas of research.

Recent findings

Palbociclib, ribociclib, and abemaciclib are each approved in combination with an aromatase inhibitor or fulvestrant for HR+ MBC. Abemaciclib is also approved as monotherapy for pre-treated patients. Key questions in the field include whether all patients with HR+ MBC should receive a CDK 4/6 inhibitor up front versus later line, impact on overall survival, role of continued CDK 4/6 blockade, mechanism of clinical resistance, and treatment sequencing. The development of CDK 4/6 inhibitors has changed the therapeutic management of HR+ MBC. Additional research

SUBMITTER: Spring LM 

PROVIDER: S-EPMC6573012 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature