Interaction Between Dietary Choline Intake During Pregnancy and Choline-metabolising Genetic Polymorphisms on the Risk of Preterm Birth (P11-037-19)

ABSTRACT: Abstract

Objectives

Adequate intake of dietary choline, an essential nutrient, is pivotal for an optimal pregnant outcome and fetal programming, which may be affected by choline-metabolising genetic polymorphisms. This case-control study aims to investigate the interaction between choline intake during pregnancy and genetic polymorphisms in choline dehydrogenase (CHDH) and betaine-homocysteine methyltransferase (BHMT) on preterm birth risk among Chinese women.

Methods

129 women with preterm delivery and 141 parturients with full-term delivery were recruited respectively at Xinhua Hospital, Shanghai between March 2016 and July 2018. Dietary choline intake during pregnancy was assessed by a validated food frequency questionnaire, genotyping was conducted for CHDH (G233C, rs

SUBMITTER: Zhu J 

PROVIDER: S-EPMC6573953 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature