MTRR 66 and SHMT1 1420 Variants Are Associated with Optic Disc Edema During 30-d Strict Head-down Tilt Bed Rest and CO2 Exposure (P24-036-19)

ABSTRACT: Abstract

Objectives

Some astronauts returning from missions to the International Space Station (ISS) have developed ophthalmic structural changes, including optic disc edema. Incidence of optic disc edema among astronauts has been linked to one-carbon pathway genetic variants and B-vitamin status. A recent 30-d 6-degree head-down tilt bed rest study in which all subjects were exposed to 0.5% CO2 documented the occurrence of optic disc edema in 5 of 11 subjects. The objective of this study was to determine the effect of one-carbon pathway genetics and B-vitamin status on the incidence of optic disc edema in the bed rest subjects.

Methods

The study was conducted at the : envihab facility at the German Aerospace Center in Cologne, Germany. Subjects (6 M/5F) were healthy volu

SUBMITTER: Smith S 

PROVIDER: S-EPMC6574058 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature