A Replication Study Identified Seven SNPs Associated with Quantitative Traits of Type 2 Diabetes Among Chinese Population (P18-079-19)

ABSTRACT: Abstract

Objectives

To explore genetic variants for quantitative traits of type 2 diabetes (T2D) such as insulin resistance and insulin release among Chinese adults.

Methods

A total of 2216 subjects were selected from cross-sectional 2010–2012 China National Nutrition and Health Surveillance. Fasting plasma glucose(FPG) and fasting serum insulin(FSIN) were tested and 81 T2D single nucleotide polymorphisms (SNPs) were genotyped. Insulin resistance was defined by exceeding top quartile of insulin resistance of homeostasis model assessment(HOMA-IR) index value and insulin release was defined under lower quartile of insulin release of homeostasis model assessment(HOMA-B) index value in nondiabetic individuals, respectively. Logisticregression model was utilized to explore ass

SUBMITTER: Liu A 

PROVIDER: S-EPMC6574642 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature