Associations of Lipid-related SNPs with Circulating Phylloquinone Are Proportional with Triglycerides (P15-008-19)

ABSTRACT: Abstract

Objectives

Phylloquinone is transported on triglyceride-rich lipoproteins. Preliminary evidence from a genome-wide association meta-analysis suggests that genetic variants that influence triglycerides (TGs), such as rs964184 at the APOA1/C3/A4/A5 gene cluster, also influence circulating phylloquinone. To further evaluate this overlap, we examined the linear relationship between a weighted TG genetic risk score (wTG-GRS) with circulating phylloquinone.

Methods

We constructed a wTG-GRS comprised of 20 SNPs that were previously associated with TGs in a genome-wide association meta-analysis for blood lipids (n > 188,000 individuals of European ancestry). The assigned weights corresponded to the effect-sizes (β) reported for each SNP's association with TGs. With meta-

SUBMITTER: Kelly J 

PROVIDER: S-EPMC6574978 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature