The Effect of a Preconception Nutrition Supplement on One Carbon Metabolites (P24-028-19)

ABSTRACT: Abstract

Objectives

Studies in both animals and humans have shown that maternal dietary restriction and supplementation of one carbon (1C) metabolites (methyl donors), such as methionine and choline, can impact offspring growth, insulin resistance, and DNA methylation. However, there has been limited longitudinal research of 1C metabolite concentrations over the reproduction cycle of human pregnancy. The purpose of this study was to investigate if 1C metabolite concentrations change prior to and during pregnancy and if a preconception lipid-based nutrition supplement (LNS) influences such changes.

Methods

This study was a secondary analysis as part of the Women First study (clinicaltrials.gov, NCT01883193), a large, randomized controlled trial investigating whether the ti

SUBMITTER: Gilley S 

PROVIDER: S-EPMC6575079 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature